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I am Russian genetic disorders Victoria, a medical student. My blog of medicine and health, fresh, interesting and useful news, I would like to describe the results of the research. My goal is that the public can people get closer genetic disorders to this science. My email: You can viki@housemd.hu Mark iwiw club as a criticism of the Cogito about the lifestyle category was the best by a jury of 10 blogs listed among the Cogito!
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"New" role of serotonin 31/01/2009. 11:19 Russian Victoria
Vanderbilt Medical Center genetic disorders researchers have revealed a surprising connection to the brain iron levels and serotonin - a neuropsychiatric disorders, such as autism or neurotransmitter in the major depression - között.- enter the Medipress. Head study published January 27 st edition of the Proceedings of the National Academy of Sciences panel, Dr. Randy Blakely, Ph.D., and colleagues have discovered genetic disorders a new character, which showed a correlation between certain genetic variants. The serotonin transporter protein (SERT) regulates the amount of serotonin available in the brain and the periphery, and the variations in human SERT was associated behavioral problems related several nervous system - including genetic disorders alcoholism, depression, obsessive-compulsive genetic disorders disorder and autism. SERT is also used to treat depression in the major target for drugs such as selective serotonin reuptake inhibitors (SSRI). Okay thanks to an animal by chance discovery genetic disorders of the first author and Blakely Ana Carnerio Ph.D. recognized genetic disorders that the mouse strain, which prejudice the operation studied - C57BL / 6 - in fact a mutation genetic disorders that reduces the transporter function. "Functioning of the human SERT variants are associated with low levels of anxiety, depression, and reduced efficacy of SSRI treatment." - Blakely, senior director of the Vanderbilt Center for Molecular Neuroscience. The Mouse Phenome Database, an online resource called discovered that most of the strains included in the SERT is a version of the "ER" is having a sequence identical to the sequence found in human SERT. However, some strains, including the commonly studied C57BL / 6 strain, carry a different version genetic disorders (the version called "GK"). Carneiro realized that the SERT GK can be identified in brain chemistry and behavior of the examination. genetic disorders David Airey Ph.D., helped Carneiro and Blakely mice were bred out where the SERT GK many different genetic backgrounds - a so-called "recombinant inbred" population created termed bxd mice. Using lines from this population, the research team found that the SERT GK mice performed differently SERT ER mice on anxiety and depression tests to show that the SERT GK lower operation. There is a public database of bxd mice anatomical, biochemical genetic disorders and behavioral characteristics, allowing Blakely-wedge for low functioning SERT identification of new strains. The group identified a number of trait differences between genetic disorders the SET GK / ER variation, including alcohol consumption and brain dopamine signaling traits associated. Additionally, they found that the brains genetic disorders of mice with GK variants had significantly higher levels of iron compared to the ER variant mice. Iron serotonin and dopamine synthesis is required, and serotonin receptors genetic disorders regulate iron-carrying proteins. But have not previously been demonstrated that the SERT control brain iron levels. Follow-up studies mouse - where the SERT gene was eliminated ("knock-out" mice) - demonstrated the transporter in controlling brain iron levels role. "Because of the SERT important gyógyszercé