2013 Springer Verlag Heidelberg

Since June 2009 (JANSSEN-Cilag PRILIGY ,) is dapoxetine the first oral drug for the treatment of premature ejaculation in Germany and Austria was granted in men aged 18 to 64 years. Dapoxetine is currently not recoverable. Prior to prescribing both a detailed medical history with focus on past orthostatic incidents and a Orthostaseprüfung must be made. Mechanism of Dapoxetine is an SSRI with a rapid onset in the approved indication and short duration of action. Many previous melanoma studies and reports have already had the ejakulationsverzögernden effects of serotonin reuptake inhibitors (SSRIs, clomipramine), common (in addition to other sexual dysfunctions), is as undesirable "side effect".
Efficacy in the pivotal studies was dapoxetine (30-60mg) or placebo at about 6,000 men with proven premature ejaculation (age 18-77 years; sexual relationship of at least 6 months) for 12 weeks tested, partners were included in the evaluations (eg Pryor et al, Lancet, 2006, 368: 929). The ejaculatory melanoma latency was significantly dapoxetine versus placebo extended (to an average of 2 to 3 times). However, the extension of the intravaginal ejaculatory latency is (about melanoma 1-2 min) under dapoxetine obviously lower than for paroxetine or clomipramine (regular use); none of these reference substances has however allowed with premature ejaculation. The side effects are typical SSRI, in the pivotal studies mainly headache, nausea and slight nausea have been reported, which disappeared a few hours after taking dapoxetine
Pharmacokinetics Tmax 1-2 h, elimination half-life is approximately 19 hours, 15-76% bioavailability, metabolism occurs primarily via CYP2D6 and CYP3A4 in particular, especially to the active metabolite desmethyldapoxetine.
Side effects Very common: nausea (at 60mg up to 30%), dizziness, headache. Common: insomnia, anxiety, agitation, anxiety, libido reduction, abnormal melanoma dreams, somnolence, disturbance in attention, tremor, paraesthesia, blurred vision, tinnitus, flushing, yawning, sinus congestion, other gastrointestinal disorders, melanoma hyperhidrosis, erectile dysfunction, fatigue, irritability, hypertension. Uncommon: melanoma including sinus arrest, tachycardia, Ejakulationsversagen, genital paresthesia, loss of libido, orgasmic dysfunction. Also described syncope melanoma are (in the majority in the first 3 hours), and orthostatic hypotension.
Contraindications Orthostatic reactions in prehistory, severe heart disease (heart failure NYHA II-IV, cardiac conduction disorders, ischemic heart disease, valvular heart disease), moderate to severe hepatic impairment, severe renal impairment, psychiatric disorders, alcohol and drugs, concomitant use of potent CYP3A4 inhibitors, thioridazine, SSRI , SNRIs, tricyclic antidepressants, MAO inhibitors, hypericum, lithium and other serotoninergic drugs.
Review The rapid onset of action makes dapoxetine as "on-demand" -Medikation in quite frequent ejaculation praecox suitable in principle, however, it remains the critical individual assessment of desirable and undesirable effects. Matthias J. Müller, Giessen and Marburg Otto Benkert, Mainz This entry was posted in drugs to treat sexual disorders Sexual disorders. Bookmark the permalink.
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2013 Springer Verlag Heidelberg