4.1 Indications for Treatment of essential hypertension in patients with candesartan cilexetil or h

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Each tablet contains 8 mg of candesartan cilexetil hiatal hernia symptoms and hydrochlorothiazide 12.5 mg. INN. Candesartanum, hydrochlorothiazide Excipients: Each tablet contains 84 mg of lactose. For a full list of excipients, see section 6.1. 3. PHARMACEUTICAL FORM
Tablet White, oval, biconvex tablet with a score line on both sides. The scoreline is only breaking for ease of swallowing in order to facilitate, not to divide into equal doses. 4. CLINICAL DATA
4.1 Indications for Treatment of essential hypertension in patients with candesartan cilexetil or hydrochlorothiazide monotherapy does not ensure an adequate blood pressure control. 4.2 Posology and method of administration For oral use. Prescanden HCT Dosage The recommended dose is 8 mg / 12.5 mg 1 time a day and 16 mg / 12.5 mg stronger effect. Before the transition hiatal hernia symptoms Prescanden HCT should be titrated to a dose of candesartan cilexetil. Monotherapy may be considered if clinically necessary immediate exchange Prescanden the HCT. The maximum antihypertensive effect is usually achieved within 4 weeks after starting treatment. Use in elderly patients do not require adjustment of the initial dose. Use in patients with intravascular volume depletion in patients who are at risk of hypotension (eg, intravascular volume depletion hiatal hernia symptoms potential patients) titrating the dose of candesartan cilexetil is recommended. These patients are recommended starting dose of 4 mg candesartan hiatal hernia symptoms cilexetil. Renal impairment of renal function, loop diuretics are preferred to thiazides disorder. Renal dysfunction in patients with creatinine clearance 30 ml / min / 1.73 m2 Prescanden HCTiga before starting treatment, it is recommended that the dose titration of candesartan cilexetil (candesartan recommended starting dose for mild and moderate renal impairment is 4 mg). Prescanden HCT should not be used in patients with severe hiatal hernia symptoms renal impairment (creatinine clearance <30 mL / min / 1.73 m2). Hepatic dysfunction with mild or moderate hepatic impairment before treatment with candesartan Prescanden HCTiga hiatal hernia symptoms recommended dose can be titrated (recommended starting dose of candesartan in patients is 2 mg). Prescanden HCT should not be used in patients with severe hepatic dysfunction and / or in patients with cholestasis. Children and adolescents (under 18 years) Prescanden HCT is not recommended for use in children hiatal hernia symptoms aged up to 18 years in relation to the lack of data on safety and efficacy. Method of administration Prescanden HCT should be administered once daily with or without food. 4.3 Contraindications Hypersensitivity to the active substance, to any of the excipients or to sulfonamide-derived substances (hydrochlorothiazide is a sulfonamide derivative) subject. 2nd and 3rd trimester of pregnancy (see sections 4.4 and 4.6). Severe renal impairment (creatinine clearance <30 mL / min / 1.73 m2). Severe hepatic impairment and / or cholestasis. A persistent hypokalemia and hypercalcemia. Gout. 4.4 Special warnings and precautions hiatal hernia symptoms for use Renal impairment / kidney transplantation, hiatal hernia symptoms renal impairment Loop diuretics are preferred to thiazides in the case. Prescanden HCT is administered to patients with renal dysfunction is recommended that periodic monitoring of potassium, creatinine and urea levels. hiatal hernia symptoms Prescanden HCT in patients with a recent hiatal hernia symptoms kidney transplant lack of experience. Renal artery stenosis Other activity hiatal hernia symptoms of the renin-angiotensin-aldosterone system-acting agents, including hiatal hernia symptoms angiotensin-converting enzyme hiatal hernia symptoms (ACE) inhibitors, may increase blood urea and serum creatinine in patients with bilateral renal artery stenosis or a single. A similar effect is also possible by the appearance of an angiotensin II receptor antagonists. Intravascular volume decreased intravascular volume reduction and / or sodium depleted patients, like other renin-angiotensin-aldosterone system medications occur, symptomatic hypotension. hiatal hernia symptoms Prescanden HCT is not recommended for use prior to the adjustment of status. Anesthesia and surgery in patients treated with angiotensin II receptor antagonists hiatal hernia symptoms may occur during anesthesia and surgical manipulation of the renin-angiotensin system blockade due to hypotension. Very rarely, hiatal hernia symptoms hypotension may be so serious that it is a legitimate use of intravenous fluids and / or vasopressors. Hepatic impairment of liver function disorders, v