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American psychiatrists from Washington University fenistil School of Medicine have found that a mental fenistil disorder like schizophrenia is at least eight different diseases. Thus, each disease has its own symptoms fenistil and genetic features. Disease, as scientists believe, is not associated with mutations in individual genes but in malfunction of 42 genetic clusters. Scientists have studied single nucleotide polymorphism (SNP) - point mutations, which are expressed in the replacement of one nucleotide by another in 4200 patients with schizophrenia and compared them with the data of mentally healthy people. So they were able to identify fenistil 42 genetic clusters, which are responsible for disease development. According to the authors, their study shows that some genes show a slight risk of developing the disease, fenistil but a group of genes - clusters that somehow interact with each other, talk about the risk of disease from 70 to 100 percent. "So far, scientists have searched for a link between mutations in individual genes and the development of schizophrenia. Moreover, fenistil upuskavsya one point: there was no understanding that these genes are not separately but together fenistil in clusters. Exactly disorganized work such clusters leads to the development of the disease, "- said one of the study's authors, Professor of Psychiatry at Washington University Dragan Shvrakych. Thus, according to the researchers, each cluster is responsible for the development of certain symptoms and is associated with a particular type of disease. For example, one group associated with the appearance of hallucinations, the other is responsible for delirium, confusion. "We have succeeded after years of misunderstanding of the process of figuring out how genes interact with each other and how disruption of the gene leads to the development fenistil of different forms of schizophrenia," - said one of the study's authors, Dr. Robert Kloninher (Robert Cloninger). Now, knowing that clusters of genes responsible for the manifestation of symptoms of the disease, according to the authors, can conduct targeted treatment that will work efficiently. "Most scientists are trying to find the role of individual genes in the development of cardiovascular disease, diabetes, and this raises many difficulties. Fact that this approach can not explain the occurrence and severity of the disease. Possible that the whole thing is not individual genes, and in clusters, in the functioning of individual genes. quite possible that our study will change the view of this problem, "- says Dr. Kloninher. Research fenistil results published in the American Psychiatric fresh issue of The American Journal of Psychiatry.
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